. Author manuscript; available in PMC: 2022 Aug 9.

Published in final edited form as: FASEB J. 2022 Apr;36(4):e22242. doi: 10.1096/fj.202100901RRR

TABLE 4.

Upstream regulators altered in Rbp1^−/− right and left ventricle

Upstream regulator	Activation z-score	B-H corrected p-value	Genes regulated by upstream regulator
Left ventricle Rbp1^−/− vs. left ventricle WT
Bvht	1.982	.0403	Hbb-b2, HBG2, MYH7, SERPINF1
Right ventricle Rbp1^−/− vs. right ventricle WT
Ifnar	2.219	.0354	B2M, GBP2, ISG15, STAT1, TAPBP
NRAS	−1.912	.0238	AKAP12, B2M, GBP2, ISG15, NPPA, OSBPL1A, PKIA, STAT1
HEY2	−1.956	.0238	MYH11, MYL4, MYL7, NPPA
PNPT1	−2	.0354	GBP2, GBP6, ISG15, STAT1
STAT6	−2.087	.0093	APOE, COBLL1, FASN, GBP2, GBP6, Ighg2b, ISG15, LIFR, PDK4, PLBD1, RAB35, SERPINA1, SERPINF1
WT right ventricle vs WT left ventricle
GATA1	2.397	.012	Ahsp, ALOX12, GP1BA, GP1BB, GP9, Hbb-b2, NHP2, PF4, SNCA, TGFB1I1
FLNA	1.964	.0072	GP1BA, GP1BB, GP9, ITGB1
Rbp1^−/− right ventricle vs Rbp1^−/− left ventricle
GATA1	2.575	.0006	Ahsp, ALOX12, CNN3, GP1BA, GP1BB, GP9, Hbb-b2, NHP2, NPPA, PF4, PLEK, TGFB1I1

Note: Criteria for upstream regulator interference were a nonzero absolute activation z-score and a Benjamini-Hochberg corrected Fisher’s exact test p-value < .01.