Table 4.
Comparison of immune responses for sIPV+DTaP versus DTaP alone.
| Antigen | Parameters of immunogenicity | Group 1, n=170 | Group 3, n=173 | P value | |
|---|---|---|---|---|---|
| Diphtheria | Seropositive, n (%),(95%CI) | Pre-vaccination | 3 (1.76), (0.37-5.07) | 10 (5.78), (2.81-10.37) | 0.040 |
| Post-vaccination | 100 (97.85-100) | 100 (97.89-100) | 1.000 | ||
| Seroconversion(%)(95%CI) | Post-vaccination | 100 (97.85-100) | 100 (97.89-100) | 1.000 | |
| GMT (95%CI) | Pre-vaccination | 0.03 (0.02-0.03) | 0.03 (0.03-0.03) | 0.280 | |
| Post-vaccination | 1.87 (1.71-2.04) | 1.83 (1.69-1.99) | 0.276 | ||
| tetanus | Seropositive, n (%),(95%CI) | Pre-vaccination | 11(6.47), (3.27-11.28) | 9(5.20), (2.41-9.65) | 0.616 |
| Post-vaccination | 100 (97.85-100) | 100 (97.89-100) | 1.000 | ||
| Seroconversion(%)(95%CI) | Post-vaccination | 100 (97.85-100) | 100 (97.89-100) | 1.000 | |
| GMT (95%CI) | Pre-vaccination | 0.03 (0.02-0.03) | 0.02 (0.02-0.02) | 0.002 | |
| Post-vaccination | 4.70 (4.38-5.03) | 4.81 (4.52-5.13) | 0.511 | ||
| PT | Seropositive, n (%),(95%CI) | Pre-vaccination | 4(2.35), (0.64-5.91) | 0(0), (0-2.11) | 0.017 |
| Post-vaccination | 97.06 (93.27-99.04) | 94.80 (90.35-97.59) | 0.290 | ||
| Seroconversion(%)(95%CI) | Post-vaccination | 94.71 (90.19-97.55) | 94.22 (89.63-97.19) | 0.844 | |
| GMT (95%CI) | Pre-vaccination | 2.25 (1.96-2.58) | 1.84 (1.63-2.07) | 0.054 | |
| Post-vaccination | 49.79 (46.28-53.55) | 51.76 (47.77-56.08) | 0.596 | ||
| FHA | Seropositive, n (%),(95%CI) | Pre-vaccination | 4(2.35), (2.35) | 2(1.16), (0.14-4.11) | 0.394 |
| Post-vaccination | 100 (97.85-100) | 100 (97.89-100) | 1.000 | ||
| Seroconversion(%)(95%CI) | Post-vaccination | 97.65 (94.09-99.36) | 100 (97.89-100) | 0.017 | |
| GMT (95%CI) | Pre-vaccination | 3.23 (2.88-3.62) | 2.79 (2.48-3.14) | 0.064 | |
| Post-vaccination | 86.11 (80.07-92.6) | 87.00 (81.81-92.52) | 0.831 | ||