Table 6.

Severity of adverse events among different groups.

AEs	Group 1 (n=234)			Group 2 (n=234)			Group 3 (n=234)			P value
	Mild,n(%)	Moderate,n(%)	Severe,n(%)	Mild,n(%)	Moderate,n(%)	Severe,n(%)	Mild,n(%)	Moderate,n(%)	Severe,n(%)
Local AEs	22 (9.4)	39 (16.67)	10 (4.39)	21 (8.97)	5 (2.14)	3 (1.32)	16 (6.84)	25 (10.68)	9 (3.95)	0.006
pain	7 (2.99)	2 (0.85)	0 (0)	4 (1.71)	1 (0.43)	0 (0)	3 (1.28)	1 (0.43)	0 (0)	0.992
induration	5 (2.14)	8 (3.42)	2 (0.88)	2 (0.85)	0 (0)	1 (0.44)	6 (2.56)	5 (2.14)	1 (0.44)	0.721
redness	20 (8.55)	35 (14.96)	9 (3.95)	20 (8.55)	4 (1.71)	3 (1.32)	15 (6.41)	24 (10.26)	9 (3.95)	0.006
swelling	2 (0.85)	4 (1.71)	2 (0.88)	0 (0)	0 (0)	1 (0.44)	1 (0.43)	0 (0)	2 (0.88)	0.485
rash	1 (0.43)	1 (0.43)	0 (0)	0 (0)	0 (0)	0 (0)	1 (0.43)	0 (0)	0 (0)	0.540
skin reactions	2 (0.85)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	–
Systemic AEs	37 (15.81)	37 (15.81)	7 (3.07)	36 (15.38)	17 (7.26)	2 (0.88)	26 (11.11)	19 (8.12)	2 (0.88)	0.115
fever	34 (14.53)	25 (10.68)	2 (0.88)	20 (8.55)	9 (3.85)	1 (0.44)	19 (8.12)	10 (4.27)	2 (0.88)	0.720
irritability	10 (4.27)	0 (0)	0 (0)	10 (4.27)	0 (0)	0 (0)	10 (4.27)	0 (0)	0 (0)	1.000
vomit	5 (2.14)	0 (0)	1 (0.44)	7 (2.99)	4 (1.71)	0 (0)	4 (1.71)	1 (0.43)	0 (0)	0.839
diarrhea	7 (2.99)	14 (5.98)	5 (2.19)	8 (3.42)	5 (2.14)	1 (0.44)	6 (2.56)	12 (5.13)	1 (0.44)	0.204
drowsiness	13 (5.56)	0 (0)	0 (0)	5 (2.14)	1 (0.43)	0 (0)	2 (0.85)	0 (0)	0 (0)	0.843
eating disorder	5 (2.14)	2 (0.85)	0 (0)	0 (0)	0 (0)	0 (0)	3 (1.28)	0 (0)	0 (0)	0.494
Allergic reaction	1 (0.43)	1 (0.43)	0 (0)	1 (0.43)	1 (0.43)	0 (0)	2 (0.85)	0 (0)	0 (0)	0.651
Others	18 (7.69)	27 (11.54)	14(6.14)	15 (6.41)	22 (9.4)	8 (3.51)	22 (9.4)	32 (13.68)	6 (2.63)	0.406