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. 2022 Jul 26;13:942482. doi: 10.3389/fimmu.2022.942482

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Copyright © 2022 Ries, Heß, Nouri, Wichelhaus, Göttig, Falcone and Kraiczy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of CipA on the enzymatic activity of the C5 convertases. The influence of CipA on the C5 convertase was analyzed by measuring the generation of C5a. The C5 convertases of the AP (A) and CP (B) were constituted on microtiter plates coated with LPS or IgM by adding NHS. Thereafter, reaction mixtures of C5 preincubated with or without CipA variants were added. The generation and release of C5a in the supernatant was then detected by C5a ELISA. Data represent means and standard deviation of at least three independent experiments, each conducted in duplicate. ***, p ≤ 0.0002; ****, p ≤ 0.0001, n.s., no statistical significance, one-way ANOVA with post-hoc Bonferroni multiple comparison test (confidence interval = 95%).