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. 2022 Aug 8;6(8):968–978. doi: 10.1038/s41551-022-00919-w

Table 1.

ROC curve analysis for electrochemical assays

Viral RNA Serology (IgG)
Electrode ORF1a RNA S1 S1-RBD N Combined
Area under the curve 1.00 0.98 1.00 0.98 1.00
95% CI (1.00, 1.00) (0.95, 1.00) (1.00, 1.00) (0.95, 1.00) (1.00, 1.00)
P value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
Cut-off 8,859 >1.9 × 10–7 >1.7 × 10–7 >3.1 × 10–8 >2.4 × 10–7
Sensitivity, 95% CI 1.00, (0.83, 1.00) 0.95, (0.83, 0.97) 1.00, (0.94, 1.00) 0.95, (0.86, 0.98) 1.00, (0.94, 1.00)
Specificity, 95% CI 1.00, (0.74, 1.00) 1.00, (0.93, 1.00) 1.00, (0.93, 1.00) 1.00, (0.93, 1.00) 1.00, (0.93, 1.00)
Number of positive samples 19 54 54 54 54
Number of negative samples 11 58 58 58 58

Summary of the numerical values of the ROC curve analysis of the patient sample data collected for the SARS-CoV-2 biomarker assays for detection of (left to right) ORF1a RNA, S1 subunit, S1-RBD, N and a combined assay. Positive and negative SARS-CoV-2 samples were confirmed by RT–qPCR. CI, confidence interval.