Table 1.
Viral RNA | Serology (IgG) | ||||
---|---|---|---|---|---|
Electrode | ORF1a RNA | S1 | S1-RBD | N | Combined |
Area under the curve | 1.00 | 0.98 | 1.00 | 0.98 | 1.00 |
95% CI | (1.00, 1.00) | (0.95, 1.00) | (1.00, 1.00) | (0.95, 1.00) | (1.00, 1.00) |
P value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
Cut-off | 8,859 | >1.9 × 10–7 | >1.7 × 10–7 | >3.1 × 10–8 | >2.4 × 10–7 |
Sensitivity, 95% CI | 1.00, (0.83, 1.00) | 0.95, (0.83, 0.97) | 1.00, (0.94, 1.00) | 0.95, (0.86, 0.98) | 1.00, (0.94, 1.00) |
Specificity, 95% CI | 1.00, (0.74, 1.00) | 1.00, (0.93, 1.00) | 1.00, (0.93, 1.00) | 1.00, (0.93, 1.00) | 1.00, (0.93, 1.00) |
Number of positive samples | 19 | 54 | 54 | 54 | 54 |
Number of negative samples | 11 | 58 | 58 | 58 | 58 |
Summary of the numerical values of the ROC curve analysis of the patient sample data collected for the SARS-CoV-2 biomarker assays for detection of (left to right) ORF1a RNA, S1 subunit, S1-RBD, N and a combined assay. Positive and negative SARS-CoV-2 samples were confirmed by RT–qPCR. CI, confidence interval.