Test name	Cognitive function assessed	Variable of interest	Value range for variable of interest
HVLT-r	Verbal memory	Total correct recall trials over three learning and one delayed recall trials; higher score indicates better performance	0–48
SDMT	Visuospatial attention, processing speed, working memory	Number of correctly coded terms; higher score indicates better performance	0–110
TMT-B*	Flexibility, visuospatial attention, psychomotor speed	Time (seconds) to complete the task; higher value indicates poorer performance	0–240
EMO	Emotion recognition	Number of negative emotions correctly identified; higher score indicates better performance	0–24
PTAP	Timing, psychomotor coordination	Reciprocal of the standard deviation of the ITI duration that occurred following cessation of pacing tones over all trials taken; higher value indicates better performance	Not defined
OTS*	Planning, working memory	Mean time to reach a correct response (seconds), averaged across ten trials; higher values indicate poorer performance	Not defined

Bold font indicates membership in the HD–CAB two-item cognitive family for coprimary endpoint in EM cohort B1. For tests with an asterisk (*), a lower value of the variable of interest indicates better performance; for all others, a higher value indicates better performance.