Cytotoxicity of the synthesized compounds against KB, HepG2, MCF7, A549, SK-LU-1, and Hek-293 cell lines.
| Entry | Comp | IC50 (μM) | |||||
|---|---|---|---|---|---|---|---|
| KB | HepG2 | MCF7 | A549 | SK-Lu-1 | Hek-293 | ||
| 1a | 5a | 1.23 ± 0.01 | 0.46 ± 0.01 | >2.5 | NAb | <0.040 | 9.35 ± 0.44 |
| 2a | 5b | 1.71 ± 0.07 | <0.036 | >2.5 | NAb | <0.036 | 7.20 ± 0.05 |
| 3a | 5c | 1.16 ± 0.01 | <0.039 | 2.19 ± 0.02 | NAb | <0.039 | 1.47 ± 0.04 |
| 4a | 5d | 1.54 ± 0.01 | <0.044 | 1.98 ± 0.04 | NAb | <0.044 | 1.34 ± 0.01 |
| 5a | 5e | >2.50 | 2.24 ± 0.01 | >2.50 | NAb | 1.65 ± 0.03 | >20 |
| 6a | 5f | 1.86 ± 0.02 | 0.47 ± 0.01 | >2.50 | NAb | 0.08 ± 0.01 | 4.78 ± 0.14 |
| 7a | 5g | 2.34 ± 0.26 | >2.50 | >2.50 | NAb | 2.22 ± 0.04 | 9.95 ± 0.01 |
| 8 | 5h | 0.57 ± 0.02 | 0.63 ± 0.02 | 1.61 ± 0.03 | 0.43 ± 0.01 | NA | 2.03 ± 0.06 |
| 9 | 5i | >2.50 | >2.50 | 2.23 ± 0.06 | 1.59 ± 0.03 | NA | 6.46 ± 0.15 |
| 10 | 5j | >2.50 | >2.50 | >2.50 | 1.12 ± 0.04 | NA | 7.17 ± 0.16 |
| 11 | 5k | >2.50 | >2.50 | >2.50 | 2.03 ± 0.05 | NA | >20 |
| 12 | 5l | 0.52 ± 0.02 | 0.53 ± 0.02 | 2.28 ± 0.07 | 1.10 ± 0.02 | NA | 2.23 ± 0.08 |
| 13 | 5m | 0.02 ± 0.01 | 0.02 ± 0.01 | 0.12 ± 0.03 | 0.62 ± 0.02 | NA | 0.03 ± 0.01 |
| 14 | 5n | 0.62 ± 0.01 | >2.50 | 1.96 ± 0.04 | 0.61 ± 0.02 | NA | 1.81 ± 0.05 |
| 15 | 5o | >2.50 | >2.50 | >2.50 | >2.50 | NA | >20 |
| 16 | Ellipticine | 1.15 ± 0.01 | 1.51 ± 0.05 | 1.82 ± 0.03 | 1.60 ± 0.02 | NA | 6.18 ± 0.11 |
a
These results were reported in our previous study.46
b
NA: not analyzed.