Table 3.

Risk factors for LTFU among 108 transgender women taking PrEP

Variable		n/N	(%)	Univariable Analysis				Multivariable Analysis
				HR	95% CI	LR	P-value	aHR	95% CI	LR	P-value
Age						4.00	0.045*			4.77	0.029*
	< 26 (ref.)	13/52	25	1.00	–			1.00	–
	≥ 26	25/56	45	1.95	1.00–3.81			2.09	1.06–4.14
Syphilis infection						3.98	0.046*			4.14	0.042*
	Non-reactive (ref.)	13/49	27	1.00	–			1.00	–
	Reactive	25/59	42	1.95	1.00–3.81			1.98	1.01–3.88
Frequency of PrEP use						1.13	0.287			1.59	0.207
	Daily (ref.)	28/86	33	1.00	–			1.00	–
	On-demand	10/22	45	1.50	0.73–3.09			1.63	0.78–3.41
Receiving PrEP within lockdown period						0.20	0.652
	No (ref.)	35/101	35	1.00	–
	Yes	3/7	43	1.33	0.41–4.31
Relationship status						< 0.01	0.999
	Single (ref.)	19/58	33	1.00	–
	With a partner	10/28	36	1.00	0.47–2.15
Occupation						0.45	0.800
	College student/unemployed	7/15	47	1.43	0.50–4.08
	Freelance/self-employed (ref.)	7/20	35	1.00	–
	Employee	11/29	38	1.18	0.46–3.04
History of taking PrEP before participation in the study						4.37	0.036*
	Yes (ref.)	4/22	18	1.00	–
	No	34/86	40	2.65	1.00–7.49
Sex worker experience						0.77	0.379
	Yes (ref.)	3/13	23	1.00	–
	No	35/95	37	1.64	0.50–5.33
Adverse effects after taking PrEP						0.17	0.677
	Yes	8/19	42	1.20	0.52–2.78
	No (ref.)	17/46	37	1.00	–
Feeling anxious after taking PrEP						2.80	0.094
	Yes	12/22	55	1.97	0.90–4.33
	No (ref.)	13/43	30	1.00	–
Hormone use						5.37	0.020*
	Yes (ref.)	14/48	29	1.00	–
	No	12/18	67	2.56	1.18 − 5.56
Condom use after taking PrEP						2.99	0.084
	Yes	19/41	46	2.15	0.86–5.38
	No (ref.)	6/24	25	1.00	–
Able to schedule a timely PrEP follow-up appointment						2.35	0.126
	Yes (ref.)	17/50	34	1.00	–
	No	8/15	53	2.00	0.86–4.68

Abbreviations: ref., reference group; HR, hazard ratio; aHR, adjusted hazard ratio; 95%CI, 95% confidence interval; n, number of LTFU participants; N, number of participants; PrEP, pre-exposure prophylaxis; LR, Likelihood Ratio test

*P-value < 0.05