. 2022 Jul 30;204(8):535. doi: 10.1007/s00203-022-03122-2

Table 5.

Main findings pertinent to the antifungal activity studies of nitroxoline

Antifungal nitroxoline
Fuchs et al. (2021)	Candida auris	a) The susceptibility of 35 clinical isolates of C. auris to nitroxoline, fluconazole, voriconazole, amphotericin B, and anidulafungin was determined via the microdilution method recommended by EUCAST b) Similarly, the susceptibility of C. auris isolates to nitroxoline and four other antifungals were determined via the disk-diffusion method	(a) Cepa-dependent antifungal activity for nitroxoline b) Nitroxoline showed good antifungal activity against different isolates of C. auris (MIC = 0.125–1 mg/L)
Cherdtrakulkiat et al. (2016)	Candida albicans Saccharomyces cerevisiae	a) The antimicrobial activity of nitroxoline and eight derivatives of 8-hydroxyquinoline was determined against the previously mentioned microorganisms using the agar dilution method b) The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was performed to determine the antioxidant activity of nitroxoline and other compounds tested c) A cytotoxicity assay was carried out for nitroxoline and other studied substances using the MTT reduction method (3–4,5-dimethyl-thiazol-2-yl-2,5-diphenyltetrazolium bromide)	a) Nitroxoline also showed good antifungal activity, evidenced by the MIC value of 42.07 µM for C. albicans and S. cerevisiae

Antifungal nitroxoline

References

Species

Methodology

Findings

Fuchs et al. (2021)

Candida auris

a) The susceptibility of 35 clinical isolates of C. auris to nitroxoline, fluconazole, voriconazole, amphotericin B, and anidulafungin was determined via the microdilution method recommended by EUCAST

b) Similarly, the susceptibility of C. auris isolates to nitroxoline and four other antifungals were determined via the disk-diffusion method

(a) Cepa-dependent antifungal activity for nitroxoline

b) Nitroxoline showed good antifungal activity against different isolates of C. auris (MIC = 0.125–1 mg/L)

Cherdtrakulkiat et al. (2016)

Candida albicans

Saccharomyces cerevisiae

a) The antimicrobial activity of nitroxoline and eight derivatives of 8-hydroxyquinoline was determined against the previously mentioned microorganisms using the agar dilution method

b) The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was performed to determine the antioxidant activity of nitroxoline and other compounds tested

c) A cytotoxicity assay was carried out for nitroxoline and other studied substances using the MTT reduction method (3–4,5-dimethyl-thiazol-2-yl-2,5-diphenyltetrazolium bromide)

a) Nitroxoline also showed good antifungal activity, evidenced by the MIC value of 42.07 µM for C. albicans and S. cerevisiae