. 2022 Jul 30;204(8):535. doi: 10.1007/s00203-022-03122-2

Table 8.

Main findings pertinent to the antiviral activity studies of nitroxoline

NITROXOLINE ANTIVIRAL
Zhang et al. (2020)	Japanese Encephalitis Virus (JEV)	a) The researchers built a Japanese encephalitis virus (JEV) encoding an eGFP reporter gene containing a fluorescent protein-coding sequence b) The stability of the eGFP-JEV produced was tested against C6/36 Aedes albopictus cells c) Assays evaluating antiviral activity were performed in eGFP-JEV gene-infected Huh7 cells with the test compound NITD008 and other substances (including nitroxoline).	(a) Nitroxoline exhibited high antiviral activity against Japanese encephalitis virus (JEV), denoted by EC₅₀ = 2.482 μM

NITROXOLINE ANTIVIRAL

References

Species

Methodology

Findings

Zhang et al. (2020)

Japanese Encephalitis Virus (JEV)

a) The researchers built a Japanese encephalitis virus (JEV) encoding an eGFP reporter gene containing a fluorescent protein-coding sequence

b) The stability of the eGFP-JEV produced was tested against C6/36 Aedes albopictus cells

c) Assays evaluating antiviral activity were performed in eGFP-JEV gene-infected Huh7 cells with the test compound NITD008 and other substances (including nitroxoline).

(a) Nitroxoline exhibited high antiviral activity against Japanese encephalitis virus (JEV), denoted by EC₅₀ = 2.482 μM