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. 2022 Aug 3;18(10):611–627. doi: 10.1038/s41581-022-00601-z

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Fig. 3 — Cellular senescence is involved in the pathogenesis of acute kidney injury (AKI) and many types of chronic kidney disease (CKD). Data from animal models suggest that senescent interstitial and tubular epithelial cells contribute to ischaemia–reperfusion injury (IRI), septic shock-induced AKI and contrast-induced AKI, as well as to AKI-to-CKD progression. Tubular epithelial cell senescence has also been detected in many forms of CKD, including obesity-related nephropathy, membranous nephropathy, lupus nephritis, minimal change disease (MCD), unilateral ureteral obstruction (UUO), IgA nephropathy (IgAN) and diabetic kidney disease (DKD). Endothelial cell, podocyte and mesangial cell senescence might also contribute to DKD.