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. 2022 Aug 4;1(8):732–747. doi: 10.1038/s44161-022-00108-7

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© The Author(s), under exclusive licence to Springer Nature Limited 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — Sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4/ROS/NLRP3/caspase 1/GSDMD pathway in severe sepsis. Pyroptotic platelets promote NET formation via ox-mtDNA, whereas NETs, in turn, lead to more platelet pyroptosis via release of S100A8/A9, forming a platelet pyroptosis–NET feedback loop.