TABLE 1.
Comparison of baseline demographic and clinical characteristics with respect to the APOE, GBA, MAPT, and SNCA genotype
| Clinical variables | APOE-ε4 non-carriers | APOE-ε4 carriers | GBA non-carriers | GBA carriers | MAPT H2 | MAPT H1/H1 | SNCA rs356219-A | SNCA rs356219-GG |
|---|---|---|---|---|---|---|---|---|
| N (%) | 676 (70.6) | 282 (29.4) | 876 (89.6) | 102 (10.4) | 298 (30.3) | 684 (69.7) | 784 (81.2) | 182 (18.8) |
| Male, N (%) | 411 (60.8) | 172 (61.0) | 533 (60.8%) | 65 (63.7%) | 180 (60.4) | 418 (61.1) | 475 (60.6) | 114 (62.6) |
| Age at diagnosis, years, mean (SD) | 69.9 (9.8) | 67.5 (9.4) | 69.4 (9.7) | 66.8 (9.7) | 69.8 (10.2) | 68.9 (9.6) | 69.3 (9.8) | 68.6 (9.7) |
| Age at baseline, years, mean (SD) | 69.7 (9.8) | 67.3 (9.4) | 69.2 (9.8) | 66.6 (9.7) | 69.5 (10.2) | 68.5 (9.6) | 69.0 (9.7) | 68.5 (9.6) |
| Age at motor symptom onset, years, mean (SD) | 68.1 (9.9) | 65.7 (9.5) | 67.6 (9.9) | 65.3 (9.4) | 67.8 (10.3) | 67.0 (9.7) | 67.5 (9.8) | 67.0 (9.8) |
| Positive family history, N (%) | 73 (10.9) | 37 (13.4) | 99 (11.5%) | 14 (13.9%) | 40 (13.7%) | 72 (10.7%) | 81 (10.5) | 28 (15.6) |
| Education, years, mean (SD) | 11.7 (3.5) | 12.1 (3.5) | 11.6 (3.4) | 11.8 (3.5) | 11.7 (3.4) | 11.9 (3.5) | 11.8 (3.5) | 11.8 (3.3) |
| MMSE score, median (IQR) | 29.0 (3.0) | 29.0 (2.0) | 29.0 (3.0) | 29.0 (3.0) | 29.0 (3.0) | 29.0 (2.0) | 29.0 (3.0) | 29.0 (2.0) |
| MDS-UPDRS III, mean (SD) | 31.6 (13.3) | 29.8 (12.3) | 31.2 (13.2) | 30.4 (11.6) | 32.0 (13.7) | 30.6 (12.8) | 30.7 (12.8) | 32.5 (14.1) |
| Hoehn and Yahr, median (IQR) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (0.6) |
Between-group differences marked in bold if P < 0.05 in adjusted analysis (multivariate linear regression as described in Methods).
Abbreviations: N, number; SD, standard deviation; IQR, interquartile range; MMSE, Mini-Mental State Examination; MDS-UPDRS III, Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III; GBA, glucocerebrosidase gene; APOE, apolipoprotein E gene; MAPT, microtubule-associated protein tau gene; SNCA, alpha synuclein gene.