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. 2022 Aug 9;13:4678. doi: 10.1038/s41467-022-32205-3

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Most differentially expressed proteins in the proteomics signatures constructed by comparing RPPA profiles of Her2E and Luminal-A BRC samples. b Gene expression profile of the genes corresponding to proteins in (a) based on RNA-seq data. c The transcriptional signature consisting of all highly differentially expressed genes (unadjusted, two-tailed P value<10⁻¹⁰). d Enrichment analysis of genes upregulated in Luminal A, and upregulated in Her2E tumors via Enrich (unadjusted Fisher Exact Test P values).