Fig 5. Resistance to bedaquiline, clofazimine, delamanid, and linezolid among Mycobacterium tuberculosis compendium isolates.

(A) The prevalence (within these data) of resistance to BDQ, CFZ, DLM, and LZD per country or origin or collection site. Phylotrees are shown for isolates phenotypically resistant to (B) BDQ, (C) CFZ, (D) DLM, and (E) LZD. Tip point colours denote lineage. Each outer track represents a gene thought to be associated with resistance and coloured blocks denote the presence of a nonsynonymous mutation in the relevant gene for a given isolate. Mutations in these genes that are either associated with sensitivity or present in >5% of the collection of isolates as a whole were ignored. BDQ, bedaquiline; CFZ, clofazimine; DLM, delamanid; LZD, linezolid.