Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 30;13(31):7197–7205. doi: 10.1021/acs.jpclett.2c01314

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 American Chemical Society

This article is made available via the PMC Open Access Subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

PMC Copyright notice

(A) Overall structure of the SARS-CoV-2 RdRp complex is shown on the left, with the catalytically active site amplified on the right. The nascent and template strands are colored in red and cyan, respectively. Nucleoside triphosphate (NTP) is shown in sticks with two Mg²⁺ ions as magenta spheres. (B) Chemical structures of adenosine triphosphate (ATP). (C) Chemical structure of remdesivir (RDV) in the triphosphate form, with the 1′-cyano group highlighted in blue. (D) Structure diagram of SARS-CoV-2 RdRp with UTP at the active site. (E) Similar to (D) but with RDV (shown in orange) embedded at the +1 site of the template strand.