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. 2022 Jul 30;13(31):7197–7205. doi: 10.1021/acs.jpclett.2c01314

Figure 4.

Figure 4

Side chain of V557L is rotated in comparison with that of V557. (A) Representative conformation of V557 with the dashed lines denoting the distance between the base of the nucleotide and the backbone (db.b.)/side-chain (ds.c.) of V557. (B) Density plot of db.b. versus ds.c. for RdRp with wildtype RNA. (C) Similar to (A) but for a V557L mutation. (D) Similar to (B) but for RdRp upon a V557L mutation. In (B) and (D), the simulations of RdRp with UTP binding at the active site were used for the calculations.