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. 2022 Jul 30;13(31):7197–7205. doi: 10.1021/acs.jpclett.2c01314

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V557L mutation relieves the inhibition exerted by RDV. (A) Diagram showing V557L allows the translocation of RDV from the +2 to the +1 site, where RDV and V557L are colored in orange and green, respectively. (B) Cartoon model showing the distance between the c.o.m. of V557L and C1′ of RA/RDV. (C) Histogram of the distance as shown in (B) when RA (black) or RDV (red) translocates. (D) Cartoon model showing the base-stacking angle between RDV/RA and the upstream nucleotide. (E) Histogram of the base-stacking angle for RA (black) or RDV (red) during translocation. (F,G) Typical conformation of RA/RDV with V557L during translocation.