Figure 3.

Response frequency of individual spike 15‐mer peptides and identification of the most frequently detected peptides. Individual peptide‐specific CD4⁺ T‐cell response frequencies of SARS‐CoV‐2 infected, vaccinated and individuals with both vaccination and infection to each of the 253 overlapping 15‐mer peptides covering the spike glycoprotein (a). Peptide numbers, corresponding amino acid positions and sequence, and the response frequency of the most frequently detected peptides (b). Mutations in the B.1.1.529 LUMs are highlighted: Mutations only found in BA.1 are depicted in blue, mutations found in BA.1, BA.2, BA.2.12, BA.4/5 and BA.2.75 are depicted in red, and mutations found in BA.2, BA.2.12, BA.4/5 and BA.2.75 are depicted in green. Mutations only found in BA.2.75 are depicted in pink.