3. Primary and secondary outcomes for the comparison in children.

Primary clinical outcomes*	Primary laboratory outcomes*	Secondary clinical outcomes*	Secondary laboratory outcomes*
Change in diastolic blood pressure (DBP, mmHg)c	Change in blood potassium (mmol/L)c	Growth changes (e.g. z‐scores for height‐ or length‐for‐age (HAZ or LAZ), weight‐for‐height (WHZ), weight‐for age (WAZ), BMI‐for‐age)i	Renal function (e.g. serum creatinine, albuminuria, urinary albumin‐to‐creatinine ratio (uACR), glomerular filtration rate (GFR))i
Change in systolic blood pressure (SBP, mmHg)c	Hyperkalaemia (e.g. number of children with serum potassium concentration   > 5.5 mmol/L, or as reported by study authors)c	Adverse events (other), excluding those that overlap with other outcomes, such as electrolyte disturbances and cardiac arrhythmias (e.g. nausea, vomiting)i	Bone health (e.g. serum alkaline phosphatase (ALP) in mmol/L)i
Hypertension (e.g. as average systolic BP (SBP) and/or diastolic BP (DBP) that is ≥ 95th percentile for gender, age, and height on ≥ 3 occasions, or as reported by study authors)c	Hypokalaemia (e.g. number of children with serum potassium concentration < 3.5 mmol/L, or as reported by study authors)c	Cardiovascular events (as reported by study author, such as stroke, myocardial infarction,  dysrhythmia)i	Hyponatraemia (e.g. number of children with serum sodium concentration < 135 mmol/L, or as reported by study authors)i
Blood pressure control (e.g. number of children achieving blood pressure threshold or blood pressure under "control", or as prespecified by study authors)c		Antihypertensive medication usei	Changes in fasting blood glucose (mmol/L)i
		All‐cause mortalityi	Changes in blood triglycerides  (mmol/L)i
		Cardiovascular mortalityi	Changes in total blood cholesterol (mmol/L)i
		Bone densitometry measures (e.g. bone mineral density changes)i	Change in 24‐hour urinary sodium excretion (mmol/24‐hours)**
			Change in 24‐hour urinary potassium excretion (mmol/24‐hours)**

Outcome ranking by WHO NUGAG ‐ Subgroup on Diet and Health: critical^c, importantⁱ and not importantⁿⁱ

* Outcomes measured at longest follow‐up

** Additional outcomes added by WHO NUGAG during the guideline development process; measured using 24‐h urine samples only (spot samples excluded)

Abbreviations:
ALP: alkaline phosphatase
BMI: body mass index
BP: blood pressure
DBP: diastolic blood pressure
GFR: glomerular filtration rate
HAZ: height‐for‐age z‐score
LAZ: length‐for‐age z‐score
NUGAG: Nutrition Guidance Expert Advisory Group
SBP: systolic blood pressure
uACR: urine albumin‐to‐creatinine ratio
WAZ: weight‐for‐age z‐score
WHZ: weight‐for‐height z‐score