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. 2022 Aug 10;2022(8):CD015207. doi: 10.1002/14651858.CD015207

7. Comparison 2: Overview of Synthesis and Included Studies (OSIS).

Study name (year) Study design (individual vs stepped‐wedge vs cluster‐randomised [and unit of randomisation, if applicable]) Country of conduct Overall risk of bias (arranged low to high) Key details of intervention (% KCl, LSSS implementation [discretionary, non‐discretionary, both], quantity, provided or purchased, co‐interventions [education, advice]) Key details of the comparator (implementation [discretionary, non‐discretionary, both], quantity, provided or household supply, co‐interventions [education, advice]) Population 
(No. of participants randomised [intervention/control], age, gender, hypertensive status, anti‐hypertensive medication use, BMI)
Outcome domains with available data (synthesis method/metric) Specific outcomes measure Time point of measurement
Toft 2020 Cluster‐randomised (families) Denmark Unclear < 30% KCl LSSS (per 100 g: approximately 8000 mg sodium; 870 mg Mg and 100 mg‐200 mg K estimated from the technical data sheet)
 
Non‐discretionary use (LSSS bread products to replace usual consumption), provided to families twice a week
 
Co‐interventions NR
Regular salt
 
 
 
 
 
Non‐discretionary use (regular wholegrain bread products for usual consumption), provided to families twice a week
 
 
Co‐interventions NR
40/52
 
9.5 (4.2)/8.4 (3.5) years
 
Female, %: 47.5/48.1
 
Normotensive
 
N/A
 
18.0 (2.9)/16.9 (2.8) kg/m2
 
Change in blood pressure
 
Change in BMI
 
24‐h urinary excretion
 
 
1. Change in DBP
2. Change in SBP
3. Change in BMI
4. 24‐h urinary sodium excretion
5. 24‐h urinary potassium excretion
1. 4 months
2. 4 months
3. 4 months
4. 4 months
5. 4 months
 
 
 

Abbreviations: 
24‐h: 24‐hour
BMI: body mass index
DBP: diastolic blood pressure
K(Cl): potassium (chloride)
LSSS: low‐sodium salt substitute
Mg: magnesium
N/A: not applicable
NR: not reported