Table 2.
Median concentrations [Q1;Q3] of erythrocyte PUFAs of study participants by status of incident stroke types
| PUFAs | Total stroke (n = 412) | IS (n = 342) | ICH (n = 53) | None-stroke (n = 7747) | Total population (n = 8159) |
|---|---|---|---|---|---|
| Total n-6 PUFAs, % | 30.5 [28.3;32.8] | 30.4 [28.3;32.7] | 30.3 [27.6;32.4] | 30.4 [28.4;32.4] | 30.4 [28.4;32.4] |
| 18:2n–6 (linoleic acid) | 11.7 [10.3;13.1] | 11.7 [10.3;13.0] | 12.2 [10.3;13.8] | 11.7 [10.5;13.0] | 11.7 [10.5;13.0] |
| 18:3n–6 (γ-linolenic acid) | 0.057 [0.037;0.089]* | 0.057 [0.037;0.089]* | 0.058 [0.037;0.095] | 0.054 [0.034;0.085] | 0.054 [0.034 0.085] |
| 20:2n–6 (eicosadienoic acid) | 0.40 [0.36;0.45] | 0.40 [0.36;0.45] | 0.43 [0.37;0.48]* | 0.40 [0.35;0.45] | 0.40 [0.35;0.45] |
| 20:3n–6 (dihomo-γ-linolenic acid) | 1.36 [1.17;1.59]* | 1.38 [1.18;1.60]* | 1.31 [1.11;1.52] | 1.29 [1.10;1.51] | 1.29 [1.11;1.51] |
| 20:4n–6 (arachidonic acid) | 13.2 [12.1;14.4] | 13.3 [12.2;14.5] | 12.9 [11.5;14.1] | 13.3 [12.1;14.3] | 13.3 [12.1;14.3] |
| 22:2n–6 (docosadienoic acid) | 0.080 [0.062;0.103] | 0.080 [0.062;0.102] | 0.088 [0.061;0.110] | 0.081 [0.065;0.102] | 0.081 [0.065;0.102] |
| 22:4n–6 (docosatetraenoic acid) | 2.67 [2.12;3.27] | 2.68 [2.15;3.26] | 2.48 [1.79;2.97]* | 2.69 [2.14;3.22] | 2.69 [2.14;3.22] |
| 22:5n–6 (docosapentaenoic acid) | 0.56 [0.41;0.79] | 0.57 [0.42;0.78] | 0.49 [0.35;0.78] | 0.56 [0.42;0.73] | 0.56 [0.42;0.73] |
| Total n-3 PUFAs, % | 6.80 [5.50;8.09] | 6.85 [5.56;8.11] | 6.33 [5.43;8.00] | 6.64 [5.56;8.04] | 6.65 [5.55;8.04] |
| 18:3n–3 (α;linolenic acid) | 0.19 [0.12;0.31] | 0.18 [0.12;0.30] | 0.24 [0.14;0.42]* | 0.19 [0.12;0.28] | 0.19 [0.12;0.28] |
| 20:3n–3 (eicosatrienoic acid) | 0.048 [0.034;0.070] | 0.048 [0.034;0.068] | 0.065 [0.044;0.100]* | 0.048 [0.034;0.068] | 0.048 [0.034;0.068] |
| 20:5n–3 (eicosapentaenoic acid) | 0.44 [0.26;0.67] | 0.45 [0.27;0.67] | 0.41 [0.28;0.70] | 0.41 [0.27;0.64] | 0.42 [0.27;0.64] |
| 22:5n–3 (docosapentaenoic acid) | 1.82 [1.53;2.14]* | 1.83 [1.52;2.13] | 1.85 [1.62;2.26]* | 1.77 [1.49;2.05] | 1.77 [1.49;2.05] |
| 22:6n–3 (docosahexaenoic acid) | 3.98 [3.05;5.30] | 4.08 [3.11;5.37] | 3.49 [2.71;4.52]* | 4.03 [3.10;5.27] | 4.03 [3.09;5.27] |
| Fatty acids ratio | |||||
| 18:3n–6/18:2n–6 | 0.0047 [0.0031;0.0084]* | 0.0048 [0.0032;0.0085]* | 0.0047 [0.0029;0.0089] | 0.0046 [0.0028;0.0073] | 0.0046 [0.0028;0.0074] |
| 20:3n–6/18:2n–6 | 0.12 [0.10;0.14]* | 0.12 [0.10;0.14]* | 0.11 [0.09;0.13] | 0.11 [0.09;0.13] | 0.110 [0.091;0.133] |
| 20:4n–6/20:3n–6 | 9.5 [8.1;11.6]* | 9.6 [8.1;11.5]* | 9.3 [8.3;11.6] | 10.0 [8.2;11.9] | 10.0 [8.2;11.9] |
| Total n–6/total n–3 | 4.51 [3.74;5.69] | 4.46 [3.73;5.67] | 4.70 [3.79;5.59] | 4.60 [3.70;5.66] | 4.60 [3.70;5.66] |
Abbreviations: ICH intracerebral hemorrhage, IS ischemic stroke, PUFA polyunsaturated fatty acid
*P < 0.05 when comparing stroke cases with non-stroke participants by Mann–Whitney U test