Table 2.

Placental omics birth outcome studies without environmental exposures

Outcome	Omics	Cohort	N	Reference
Birth weight	DNA methylation	-	86	Rumbajan 2016 [61]
		NICHD-FGS	301	Tekola-Ayele 2019 [62]
			301	Tekola-Ayele 2020 [60]
	mRNA expression	ELGAN	390	Payton 2020 [63]
	mRNA expression, miRNA expression, DNA methylation	ELGAN	378	Clark 2021 [40]
Fetal growth	DNA methylation	NICHD-FGS	301	Tekola-Ayele 2019 [62]
		-	17	Chen 2018 [64]
			12	Shen 2020 [65]
			51	Díaz 2017 [66]
			154	Rondinone 2021 [67]
	mRNA expression		20	Gibbs 2019 [68]
		RICHS	200	Deyssenroth 2017 [69]
	lncRNA expression, mRNA expression	-	8	Song 2018 [70]
	microRNA expression		31	Thamotharan 2017 [71]
			68	Östling 2019 [72]
Growth restriction	mRNA expression	-	14	Maulik 2016 [73]
			20	Gibbs 2021 [68]
	mRNA expression, H3K27ac		9	Paauw 2018 [74]
	DNA methylation		38	He 2016 [75]
			16	Roifman 2016 [76]
			16	Lee 2021 [77]
			17	Chen 2018 [64]
	circRNA expression		6	Wang 2020 [78]
	microRNA expression		36	Li 2019 [79]
			31	Thamotharan 2017 [71]
Preterm birth	mRNA expression	-	15	Ackerman 2016 [80]
			32	Brockway 2019 [81]
			31	Lien 2021 [82]
			133	Paquette 2018 [83]
		CBCNPBP	90	Wang 2021 [84]
	DNA methylation	-	44	Konwar 2018 [85]
			48	Wang 2019 [86]
			9	Schuster 2019 [87]
			40	Wang 2020 [88]
Autism diagnosis	DNA methylation, mRNA expression	ELGAN	379	Santos 2020 [89]
	DNA methylation	-	20	Bahado-Singh 2021 [90]
Childhood adiposity	DNA methylation	Gen3G	187	Gagné-Ouellet 2020 [91]
Newborn neurobehavior	DNA methylation	RICHS	335	Paquette 2016 [92]