Fig. 2.
Chronic inflammatory pathways associated with ESCC and their role in aiding carcinogenesis in ESCC. (A) Downstream inflammatory signaling pathways (IL-6/STAT3, NF-kB) implicated in the development and progression of esophageal carcinogenesis (B) Induction of tumor cell growth, invasion, and angiogenesis by chronic exposure to gastric acid and bile salts and the role of inflammatory microenvironment in the development of esophageal carcinoma