Table 6.
Kendall correlation coefficient between clinical outcome (row) and polygenic risk score (PRS) for healthy controls (HC) (left) and Parkinson’s disease patients (PD) (right), with annotation by bold indicating significant effect where minus value indicates negative significant effect and positive value positive significant effect respectively (Kendall correlation test).
| Clinical symptoms and scales | HC | PD |
|---|---|---|
| H&Y | 0.0272 | 0.0272 |
| MDS-UPDRS III | −0.0088 | −0.0341 |
| MDS-UPDRS II | −0.0242 | 0.0058 |
| LEDD (g/day) | 0.0091 | −0.0147 |
| Gait disorder* | 0.4070 | −0.0177 |
| Repetitive falls* | 0.6209 | 0.1690 |
| MDS-UPDRS IV | 0.0625 | 0.0625 |
| Dyskinesia/day (hours) | 0.0576 | 0.0576 |
| OFF time/day (hours) | 0.0100 | 0.0100 |
| Dystonia/day (hours) | 0.0491 | 0.0491 |
| Dyskinesia* | – | 0.1426 |
| Motor fluctuations* | – | 0.0864 |
| Freezing of gait* | – | 0.0084 |
| MoCA | 0.0542 | −0.0493′ |
| Sniffin’ stick test | 0.1012 | 0.0576 |
| PDQ-39 | −0.0519 | 0.0386 |
| SCOPA-AUT | −0.0113 | 0.0150 |
| MDS-UPDRS I | −0.0556 | 0.0105 |
| BDI-I | −0.0155 | 0.0290 |
| Starkstein Apathy Scale | −0.0425 | −0.0068 |
| PDSS | −0.0128 | −0.0332 |
| Probable RBD* | −0.1142 | −0.0703 |
| Excessive daily sleepiness* | 0.1638 | −0.1261 |
| Insomnia* | −0.0356 | 0.1387 |
| Hallucinations* | −0.9806 | −0.1225 |
| Impulse Control Disorder* | −2.1177 | −0.0872 |
| Orthostatic hypotension* | 0.0839 | −0.1331 |
| Dysphagia* | −0.6401 | −0.2650′ |
| Constipation* | 0.2701 | −0.0740 |
| Urinary Incontinence* | 0.1011 | 0.0434 |
Single and double ticks indicate significance at the 5% level and the Bonferroni-adjusted 5% level. The binary variables are annotated by asterisk. Clinical symptoms and scales are described in Supplementary Material.