Table 7.

Multiple regression model with coefficients shown from linear regression of numerical outcome and from logistic regression of binary outcome on disease duration, age at assessment (AAA) and polygenic risk score (PRS) in PD group.

Clinical symptoms and scales	Intercept	Disease duration	AAA	PRS
H&Y	0.17	0.05″	0.03″	−0.02
MDS-UPDRS III	4.44	0.76″	0.39″	−0.57
MDS-UPDRS II	1.81	0.63″	0.10′	−0.47
LEDD (g/day)	0.32	0.04″	0.00	0.01
Gait disorder*	−2.29	0.09″	0.03′	−0.04
Repetitive falls*	−5.91	0.14″	0.05′	0.15
MDS-UPDRS IV	3.37	0.28″	−0.04′	0.03
Dyskinesia/day (hours)	−0.36	0.12″	0.01	0.04
OFF time/day (hours)	0.87	0.06″	−0.01	−0.04
Dystonia/day (hours)	0.15	0.01″	0.00′	0.01
Dyskinesia*	−1.62	0.18″	−0.02	−0.05
Motor fluctuations*	−0.12	0.18″	−0.04′	−0.12
Freezing of gait*	−2.66	0.17″	0.01	−0.13
MoCA	37.25	−0.07′	−0.19″	0.40′
Sniffin’ stick test	12.64	−0.11″	−0.06″	−0.22
PDQ-39	30.96	1.86″	−0.01	−2.98′
SCOPA-AUT	2.74	0.47″	0.15″	−0.98′
MDS-UPDRS I	6.29	0.36″	0.03	−0.84′
BDI-I	6.81	0.27″	0.03	−0.76′
Starkstein Apathy Scale	6.99	0.00	0.10″	−0.18
PDSS	116.69	−1.00″	−0.10	0.12
Probable RBD*	−2.07	0.12″	0.00	−0.21
Excessive daily sleepiness*	−1.23	0.07″	0.00	−0.20
Insomnia*	−1.04	0.04′	−0.01	0.11
Hallucinations*	−2.95	0.10″	0.01	−0.23
Impulse Control Disorder*	−1.37	0.11″	−0.03	−0.25
Orthostatic hypotension*	−1.64	0.06′	0.01	−0.20
Dysphagia*	−1.77	0.07″	0.00	−0.37′
Constipation*	−2.07	0.08″	0.02′	−0.13
Urinary Incontinence*	−3.67	0.05′	0.04″	0.06

Single and double ticks indicate significance at the 5% level and the Bonferroni adjusted 5% level, the bold indicates significant effect where minus value indicates negative significant effect and positive value positive significant effect respectively. The binary variables are annotated by asterisk. Clinical symptoms and scales are described in Supplementary Material.