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. 2022 Aug 9;13:4663. doi: 10.1038/s41467-022-32347-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A graphical summary of the major changes occurring in KiDKO mice is presented. In addition to changes in the number/survival of Kiss1 neurons, as well as expression of Kiss1, kisspeptin and NKB, in the AVPV and ARC of KiDKO vs. control mice, a recapitulation of major hormonal and reproductive (gonadal) alterations was observed in KiDKO animals is provided for both males and females. RS round spermatid, ES elongated spermatid, AF antral follicle, OV ovulatory follicle, Atr.F atretic follicle, CL corpus luteum.