Table 3.

Associations between maternal depressive symptoms and infant white matter.

		EPDS model			EPDS x Sex (female) model			Model fit
Tract	Metric	B	t	p (q)	B	t	p (q)	R2	F(df)
UF-L	FD	0.0005	2.96	0.003 (.027)*				0.58	F(6,385) = 90.11
	FDC				−0.0008	−2.62	0.009 (0.054)	0.73	F(8,383) = 134.1
	Log(FC)	−0.0007	−1.33	0.183				0.72	F(7,384) = 143.4
UF-R	FD	0.0006	3.04	0.003 (0.027)*				0.57	F(6,385) = 87.92
	FDC	0.0004	2.30	0.022 (0.099)				0.74	F(7,384) = 158.3
	Log(FC)	−0.0007	−1.37	0.171				0.74	F(7,384) = 157.6
CD-L	FD	0.0003	1.66	0.099				0.34	F(6,385) = 35.1
	FDC	0.0003	2.10	0.037 (0.133)				0.65	F(7,384) = 102.8
	Log(FC)	0.0003	0.53	0.592				0.78	F(7,384) = 201.2
CD-R	FD	0.0002	1.40	0.160				0.37	F(6,385) = 38.89
	FDC	0.0003	1.71	0.088				0.66	F(7,384) = 110.6
	Log(FC)	0.0003	0.52	0.607				0.74	F(7,384) = 157.9
CV-L	FD	0.0002	1.23	0.218				0.40	F(6,385) = 45.04
	FDC	0.0002	1.10	0.271				0.66	F(7,384) = 110
	Log(FC)	−0.0001	−0.32	0.750				0.80	F(7,384) = 223.9
CV-R	FD	0.0002	1.21	0.228				0.44	F(6,385) = 51.8
	FDC	0.0001	0.91	0.362				0.68	F(7,384) = 120.3
	Log(FC)	−0.00007	−0.16	0.870				0.79	F(7,384) = 214

All models (R squared) were significant at p < 0.001. The R squared values reported are the adjusted ones, given that models have different numbers of variables. Covariates were gestational age at birth, postmenstrual age at scan, infant sex, maternal IMD at enrolment, maternal history of mental health. In addition, for FDC and log(FC) models, ICV was also included as a covariate. If EPDS by sex interaction was not significant, it was removed from the model and these cells are blank.

UF-L left uncinate fasciculus, UF-R right uncinate fasciculus, CD-L left dorsal cingulum, CD-R right dorsal cingulum, CV-L left ventral cingulum, CV-R right ventral cingulum, B = unstandardized coefficients, q = p values after FDR correction.

*Results that survive FDR correction for multiple comparisons.