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. 2022 Aug 9;13:4670. doi: 10.1038/s41467-022-32319-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a pQTMs that had P < 4.5 × 10⁻¹⁰ (Bonferroni threshold for multiple testing adjustment) in the fully-adjusted MWAS are plotted as individual points (dark blue) with chromosomal locations of the 191 protein genes (upper) and the 1837 CpGs (lower) on the x-axis. 19 proteins with ≥10 associations with CpGs are highlighted in turquoise and labelled on the upper plot. Nine CpGs with ≥6 associations with protein levels are highlighted in turquoise on the lower plot. Results were generated through linear regression models. Full summary statistics with full P values can be accessed in Supplementary Data 6. b A selection of CpGs with highly pleiotropic signals in the fully-adjusted MWAS and the corresponding function of the gene the CpGs were located within. Created with BioRender.com.