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. 2022 Aug 9;13:4670. doi: 10.1038/s41467-022-32319-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Three trans associations with the CpG site cg06690548 in the SLC7A11 gene, which encodes a synaptic protein that is involved in glutamate transmission and oxidative stress. cg06690548 has been implicated in methylome-wide studies of Parkinson’s disease and Amyotrophic lateral sclerosis (ALS) risk. b Five trans associations between CpGs in the ITIH3/ITIH1/NEK4 region on chromosome 3 and the levels of RBL2, which was associated with lower Global Grey Matter Volume. The RBL2 gene has been implicated in genome-wide associations studies (GWAS) of cognitive ability, intelligence and educational attainment. The ITIH3/ITIH1/NEK4 region has been implicated in GWAS of Schizophrenia and Bipolar disorder. c Two trans associations between DNAm at cg11294350 in the CHPT1 gene and two proteins with lysosomal-associated function (SMPD1 and HEXB) that were associated with higher Relative Brain Age and lower General Fractional Anisotropy. Associations with a positive beta coefficient are denoted as red connecting lines, whereas associations with a negative beta coefficient are denoted as blue connecting lines. The full 35 pQTMs for protein markers of brain health (15 trans and 20 cis) can be found in Supplementary Data 20. All associations were generated using linear regression and were adjusted for multiple testing. Created with BioRender.com.