Fig. 1.

Example of multimodal MR brain imaging for a single iNPH patient. (a) T1-weighted images and superimposed WM (yellow) and GM (light blue) masks. (b) WM and GM regions of interest: posterior limb of the internal capsule (PLIC, light blue); cingulum bundle (CING, red); thalamus (THAL, violet); posterior cingulate cortex (PCC, green). (c) Brain morphology: the blue-to-white colormap represents probability maps for the posterior callosal marginal fissures (PCMF), the ventricles, and the calcarine fissures (CF). (d) T2-weighted axial slice: red arrows indicate WM hyperintensities. (e) ODI (dark red indicates lower ODI values, corresponding to more packed and less fanned out WM fibers) and V_ic (lighter blue indicates higher V_ic values, corresponding to larger intra-axonal volume fraction) axial slices derived from NODDI reconstruction of DWI data. (f) Relative blood perfusion derived from ASL data superimposed on a T1-weighted slice (yellow-white indicates higher relative perfusion). (g) Standardized rs-fMRI values from a single time point corresponding to PCC activation, superimposed on a T1-weighted slice [yellow–red (light blue) indicates co-activation (co-deactivation) with the PCC; only rs-fMRI values of cortical voxels are shown]