Table 1.
Demographics and CSF biomarkers of iNPH patients responding and not responding to CSFTT, and healthy controls
| Characteristics | iNPH RSPa (n = 16) | iNPH nRSPa (n = 14) | p-valueb RSP/nRSP | HCa (n = 46) | p-valuec RSP/HC | p-valuec nRSP/HC |
|---|---|---|---|---|---|---|
| Age (years) | 79.3 (6.6) | 79.4 (5.2) | 0.95 | 74.7 (5.4) | 0.0081 | 0.0059 |
| Gender, female (n (%)) | 6 (37%) | 6 (43%) | 0.76 | 35 (76%) | 0.0050 | 0.019 |
| Education level (I/II/III)—median [interq] | 2 [1.0, 2.5] | 1 [1.0, 1.0] | 0.092 | 3 [2.0, 3.0] | 0.0069 | 0.000065 |
| Aβ1-42 (ng/l) | 757.9 (282.5) | 677.0 (231.5) | 0.40 | – | – | – |
| pTau (ng/l) | 45.8 (14.6) | 42.6 (12.8) | 0.54 | – | – | – |
| tTau (ng/l) | 242.1 (113.9) | 236.6 (93.4) | 0.89 | – | – | – |
iNPH idiopathic normal pressure hydrocephalus, RSP responder, nRSP non-responder, HC healthy control, interq interquartile range, Aβ1-42 42 amino-acid form of beta-amyloid, pTau phosphorylate tau, tTau total tau
aGroup-level mean (standard deviation), median [25th–75th interquartile range] or number of subjects (percentage) per class are reported as appropriate
bStudent’s t test, Chi-square (gender) or Mann–Whitney U test (education level) were used as appropriate
cGeneralized linear model including age as covariate. Results were unchanged when adding gender or education level as covariates. Age, gender and education level were compared using Student’s t test, Chi-square and Mann–Whitney U test, respectively