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. 2022 Aug 9;12:13570. doi: 10.1038/s41598-022-17447-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of the drug combinations on viability of PC3-DR and DU145-DR cells. (a), PC3-DR cells were pretreated with tariquidar (TQD, 50 nM) for 30 min and then co-treated with the indicated drugs for 48 h. (b,c), PC3-DR (b) and DU145-DR (c) cells were co-treated with docetaxel (Doce) or cabazitaxel (Caba) in combination with diterpenes 1 or 5 at the indicated concentrations. Cellular viability was measured using MTT assay. The cytotoxicity heat-maps (viability inhibition) as well as synergistic/additive/antagonistic effects of drug combinations were analyzed and visualized using SynergyFinder 2.0 software (https://synergyfinder.fimm.fi/) using a ZIP algorithm (b,c). Red areas indicate synergistic effects of the drug combinations. *p < 0.05, one-way ANOVA test.