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(a) Synthesis of Qβ-GD2 conjugates. Sera from mQβ-GD2 conjugate (b) elicited significantly higher anti-GD2 IgG antibody titers, and (c) exhibited significantly higher complement mediated cytotoxicity toward tumor cells compared with those of the corresponding wtQβ-GD2 conjugate. CDC toward EL4 cells was determined by the MTS assay. Each symbol represents one mouse (n = 5 mice for each group). *p < 0.05. The p values were determined through a two tailed t test using GraphPad Prism.
