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. 2022 Feb 10;29(8-9):1240–1251. doi: 10.1038/s41417-022-00431-y

Fig. 2. Encoding suicide genes in the oFV backbone accelerates cancer cell death in vitro upon prodrug treatment.

Fig. 2

A Viability of indicator U251-U3-mCherry and CT-26-U3-mCherry cancer cell lines mock infected or infected with oFV-GFP or oFV-TK at MOI = 1 and treated with 20 μM GCV or mock control (results presented as percent of mock-treated control, experiment performed in triplicates, statistical significance determined using the Holm-Sidak method), B Percent of mCherry positive cells after mock, oFV-GFP or oFV-iCasp9 infection at MOI = 1 and treatment with AP20187 or mock control in indicator U251-U3-mCherry and CT-26-U3-mCherry cancer cell lines (measured 24 hours post AP20187 treatment, statistical significance determined using the Holm-Sidak method, performed in triplicates). C Spread of oFV, oFV-GFP, oFV-TK and oFV-iCasp9 in BHK-U3-mCherry cells (MOI = 0.01).