Table 4.

Inhibitory activity of N-alkyl derivatives of β-valienamine and 4-epi-β-valienamine. (a) Inhibitory activity of N-octyl-β-valienamine (NOV) and its N-alkyl homologues. (b) Inhibitory activity of N-octyl-4-epi-β-valienamine (NOEV).

(a)
Compound		Inhibitory activity (IC50, µM) β-Glucocerebrosidase (mouse liver)
26 (NOV)	n = 7	0.03
141a	n = 3	10
b	n = 5	0.3
c	n = 9	0.07
d	n = 13	0.12
e	n = 17	0.3

(b)
Compound	Inhibitory activity (IC50, µM)
	β-Galactocerebrosidase (mouse liver)	β-Galactosidase (bovine liver)
27 (NOEV)	5.0	0.87