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. 2022 Jul 27;13:907636. doi: 10.3389/fimmu.2022.907636

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Copyright © 2022 Cui, Xu, Hu and Lv

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polarized TAMs promote PrC cell growth through TGFβ1 (A) RT-qPCR for TGFβ1 mRNA level in CD206+ versus CD206- macrophages. (B) A transwell co-culture diagram of DU145 cells and bone-marrow-derived macrophages (MΦ). Group 1: MΦ. Group 2: MΦ with inhibitor SB431542 (SB). Group 3: MΦ and DU145 cells. Group 4: MΦ and DU145 cells transduced with shSPC25. Group 5: MΦ and DU145 cells with SB. Cells were incubated for 2 days. (C, D) Flow cytometry analysis of CD206+ cells in macrophages, shown by quantification (C) and by representative flowcharts (D). (E) MTT assay on DU145 cells. *p < 0.05. NS, non-significant. n = 5.