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. 2022 Jul 27;13:907636. doi: 10.3389/fimmu.2022.907636

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Copyright © 2022 Cui, Xu, Hu and Lv

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPC25 activates PDGF through Egr-1 (A, B) Mithramycin A (MMA) was added at a dose of 0.1 µg/ml into the cultured LNCap cells. (A) Representative Western blots of SPC25, Egr-1, and PDGF, and (B) corresponding quantification. (C) A schematic of the model in this research: SPC25 in PrC cells enhances PDGF production likely through Egr-1 to polarize macrophages towards TAM through their surface expression of PDGFR. Polarized macrophages (TAM) produce TGFβ1 to promote growth of PrC cells. *p < 0.05. NS, non-significant. n = 5.