Table 1.
The functions of ADSCs-derived EVs in diabetic foot ulcers.
| Non-coding RNAs | Target | Functions | Reference |
|---|---|---|---|
| miR-19b | CCL1 | Activate TGF-β pathway, inhibit inflammation, and reduce the apoptosis of cells | (84) |
| miR-21 | TGF-β1 | Elevate HaCaT cells migration and proliferation by enhancing the MMP-9 and depressing TIMP-2 expression via PI3K/AKT pathway | (85) |
| miR-31 | HIF-1 | Promote cell migration and tube formation of HUVECs | (86) |
| miR-125a | DLL4 | Transfer to vascular endothelial cells and promote endothelial tip cell specification to stimulate angiogenesis | (87) |
| miR-125a-3p | PTEN | Promote the viability, migration, and angiogenesis of HUVECs | (88) |
| miR-210 | RUNX3 | Promote HUVECs cell proliferation, migration, and invasion | (89) |
| miR-486-5p | Sp5 | Facilitate fibroblasts proliferation, migration, and HMECs angiogenesis | (90) |
| miR-423-5p | Sufu | Promote angiogenesis | (91) |
| miR-126-3p | PIK3R2 | Promote proliferation and migration of fibroblasts and angiogenesis of HUVECs | (92) |
| mmu_circ_0000250 | miR-128-3p | Promote SIRT1 expression and enhance angiogenesis | (93) |
| circ-Gcap14 | miR-18a-5p | Upregulate HIF-1α and VEGF expression elevation and angiogenesis | (94) |
| LncRNA H19 | miR-19b | Upregulate SOX9 to activate the Wnt/β-catenin signaling pathway and promote human skin fibroblast cell proliferation, migration and invasion | (95) |
| Linc00511 | PAQR3 | Upregulate Twist1 and EPCs proliferation, migration, and angiogenesis | (96) |
| LncRNA MALAT1 | miR-124 | Activate Wnt/β-catenin pathway, thereby promoting cutaneous wound healing | (97) |
miR/miRNA, microRNA; CCL1, C-C motif chemokine ligand 1; TGF-β, transforming growth factor beta; TGF-β1, transforming growth factor beta1; MMP-9, matrix metalloproteinase 9; TIMP-2, tissue inhibitor of matrix metalloproteinases-2; PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT, protein kinase B; HIF-1, hypoxia-inducing factor alpha; DLL4, delta-like 4; PTEN, phosphatase and tensin homolog; RUNX3, RUNX family transcription factor 3; Sp5, Sp5 transcription factor; Sufu, suppressor of fused homolog; PIK3R2, phosphoinositide-3-kinase regulatory subunit 2; circ-, circRNA; SIRT1, sirtuin 1; VEGF, vascular endothelial growth factor; SOX9, SRY-box transcription factor 9; PAQR3, progestin and adipoQ receptor family member 3; MALAT1, metastasis-associated lung adenocarcinoma transcript 1.