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. 2022 Jul 27;9:941912. doi: 10.3389/fcvm.2022.941912

Table 2.

Correlations of cardiometabolic and electrocardiographic markers with left ventricular diastolic parameters in physically active young male adults.

E/A e′ E/e′
Univariate Multivariable Univariate Multivariable Univariate Multivariable
R β (95% CI) p β (95% CI) p R β (95% CI) p β (95% CI) p R β (95% CI) p β (95% CI) p
Cardiometabolic markers
Systolic BP 0.15 −0.009
(−0.012, −0.007)
<0.001 −0.001
(−0.004, 0.002)
0.61 0.14 −0.092 (−0.120, −0.064) <0.001 −0.007 (−0.044, 0.030) 0.72 0.15 0.020
(0.014, 0.026)
<0.001 0.007
(−0.001, 0.016)
0.07
Diastolic BP 0.20 −0.015
(−0.019, −0.012)
<0.001 −0.004
(−0.008, 0.000)
0.06 0.19 −0.152 (−0.187, −0.117) <0.001 −0.069 (−0.116, −0.021) 0.004 0.15 0.027
(0.019, 0.034)
<0.001 0.010
(0.000, 0.020)
0.061
Total cholesterol 0.13 −0.003
(−0.004, −0.002)
<0.001 −0.001
(−0.002, 0.000)
0.27 0.12 −0.030 (−0.040, −0.019) <0.001 −0.010 (−0.022, 0.002) 0.09 0.07 0.004
(0.001, 0.006)
0.002 −2.337*10−5
(−0.003, 0.003)
0.98
HDL-C 0.08 0.006
(0.003, 0.009)
<0.001 0.001
(−0.002, 0.005)
0.44 0.08 0.063 (0.028, 0.098) <0.001 0.027 (−0.012, 0.066) 0.17 0.09 −0.015
(−0.022, −0.007)
<0.001 −0.005
(−0.014, 0.003)
0.23
Triglycerides 0.13 −0.001
(−0.002, −0.001)
<0.001 4.574*10−5
(0.000, 0.001)
0.84 0.11 −0.011 (−0.015, −0.007) <0.001 0.001 (−0.004, 0.007) 0.60 0.11 0.002
(0.001, 0.003)
<0.001 0.001
(−0.001, 0.002)
0.36
Fasting glucose 0.10 −0.007
(−0.010, −0.004)
<0.001 0.000
(−0.003, 0.003)
0.86 0.09 −0.062 (−0.094, −0.031) <0.001 −0.004 (−0.036, 0.028) 0.78 0.08 0.012
(0.005, 0.019)
0.001 0.002
(−0.005, 0.009)
0.51
Serum uric acid 0.09 −0.057
(−0.082, −0.031)
<0.001 −0.020
(−0.045, 0.006)
0.12 0.08 −0.496 (−0.766, −0.226) <0.001 −0.061 (−0.345, 0.222) 0.67 0.09 0.117
(0.059, 0.175)
<0.001 0.035
(−0.027, 0.098)
0.26
WC 0.21 −0.018
(−0.021, −0.014)
<0.001 −0.006
(−0.010, −0.002)
0.003 0.21 −0.182 (−0.220, −0.145) <0.001 −0.093 (−0.138, −0.047) <0.001 0.17 0.032
(0.024, 0.040)
<0.001 0.015
(0.005, 0.025)
0.004
Electrocardiographic markers
P duration (ms) 0.07 −0.004
(−0.006, −0.002)
<0.001 −0.002
(−0.004, 0.001)
0.17 0.06 −0.032 (−0.056, −0.009) 0.007 −0.009 (−0.035, 0.017) 0.49 0.01 0.001
(−0.004, 0.006)
0.72 −0.004
(−0.009, 0.002)
0.19
PR interval (ms) 0.03 −0.001
(−0.003, 0.000)
0.15 0.001
(−0.001, 0.003)
0.20 0.06 −0.028 (−0.047, −0.008) 0.005 −0.008 (−0.030, 0.013) 0.44 0.05 0.004
(0.000, 0.009)
0.04 0.004
(−0.001, 0.008)
0.12
QRS duration (ms) 0.01 0.001
(−0.003, 0.004)
0.58 −0.002
(−0.006, 0.001)
0.17 0.02 −0.013 (−0.049, 0.024) 0.49 −0.034 (−0.070, 0.002) 0.067 0.02 0.004
(−0.004, 0.012)
0.36 0.006
(−0.002, 0.014)
0.12
QTc interval (ms) 0.16 −0.005
(−0.007, −0.004)
<0.001 0.001
(0.000, 0.003)
0.12 0.05 −0.017 (−0.033, −0.002) 0.02 0.022 (0.004, 0.040) 0.01 0.05 0.004
(0.000, 0.007)
0.02 −0.001
(−0.005, 0.003)
0.78
QRS axis (degree) 0.13 0.003
(0.002, 0.005)
<0.001 0.002
(0.001, 0.003)
0.001 0.11 0.031 (0.019, 0.043) <0.001 0.019 (0.007, 0.031) 0.002 0.05 −0.003
(−0.005, 0.000)
0.03 −0.001
(−0.004, 0.002)
0.51

Multiple regression analysis was used to determine the association of left ventricular diastolic parameters with age, 3,000-m running time, pulse rate, cigarette smoking, alcohol intake status and cardiometabolic markers (systolic BP, diastolic BP, total cholesterol, HDL-C, serum triglycerides, fasting glucose, serum uric acid, waist circumference). Another multiple regression analysis was used to determine the association of left ventricular diastolic parameters with age, 3,000-m running time, pulse rate, cigarette smoking and alcohol intake status and electrocardiographic markers.

BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; WC, waist circumference.