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. 2022 Jul 27;13:970117. doi: 10.3389/fimmu.2022.970117

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Copyright © 2022 Hu, Gao, Shi, Zhang, Shi, Wen, Wang, Guo and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of necroptosis in tumor microenvironment (TME). (A) The expression of 115 necroptosis-associated genes between tumor and normal tissue. (B) The distribution of all samples using principal component analysis (PCA) in TCGA-LIHC dataset. (C) Kaplan–Meier curves of overall survival (OS) according to the necroptosis score in TCGA-LIHC dataset. (D) Correlations between 28 immune cell infiltration and necroptosis score using Spearman’s analysis. (E) Correlations between stromal score generated from estimate algorithm and necroptosis score. (F) Correlations between immune score generated from estimate algorithm and necroptosis score. *p < 0.05, ***p < 0.001.