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. 2022 Jul 27;14:955258. doi: 10.3389/fnsyn.2022.955258

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Copyright © 2022 Hölscher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the dual agonist DA4-JC in the 3xtg mouse model of AD. (A) LTP is rescued by the drug in the hippocampus. (B) No effect was seen on paired-pulse facilitation (PPF). (C) Electron microscopy of synapses in the hippocampus showed that the average area of the synapse was larger in 3xTg-AD + PBS mice, which was normalized by DA4-JC. (D) The number of synapses was lower in 3xTg-AD + PBS mice, which was increased by DA4-JC. (E) Typical Golgi stain images of dendritic spines of the hippocampus in four groups. (F) The number of dendritic spines was less in 3xTg-AD + PBS mice, while DA4-JC prevented this reduction. Modified from Cai et al. (2021). ***p < 0.001.