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. 2022 Jul 27;14:955258. doi: 10.3389/fnsyn.2022.955258

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Copyright © 2022 Hölscher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between liraglutide and DA4-JC in the APP/PS1 mouse model. (A) Water maze acquisition. DA4-JC facilitated learning more than liraglutide. (B) Recall test of the task. DA4-JC improved memory recall compared to liraglutide. *p < 0.05; **p < 0.01; ***p < 0.01. N = 12 per group. (C) Sample swim tracks of mice are shown. (D) LTP in area CA1 of the hippocampus is improved by DA4-JC more than by liraglutide. The saline group did not develop significant LTP. N = 6 per group. Modified from Maskery et al. (2020).