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. 2022 Jul 27;14:955258. doi: 10.3389/fnsyn.2022.955258

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Copyright © 2022 Hölscher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DA5-CH effectively reversed the impairment of LTP in area CA1 in APP/PS1 mice. (A) Scatter plots showing the changes of fEPSP slope in different groups. After the application of three sets of HFS, LTP was induced in all groups, but the maintenance of LTP was impaired in APP/PS1 + Saline mice, and responses went back to baseline. DA5-CH rescued LTP in APP/PS1 mice, comparable to DA4-JC. N = 6 per group. (B) Representative fEPSP traces before (black) and 180 min after (red) HFS. (C) Paired-pulse facilitation (PPF) percentage in area CA1. No change was observed at this age in this mouse model. Insets: representative PPF traces. Modified from Cao et al. (2018).