FIGURE 4.

Accuracy of the biomarker signature. a) Biomarker signature derived from LASSO regression analysis based on patients with a positive QuantiFERON-TB Gold Plus (QFT) versus low-negative QFT result. Includes only training data. b, c) Receiver operating characteristic curve plots showing the prediction accuracy of the model allowing discrimination b) between patients with tuberculosis (TB) infection (based on a positive QFT result) and without TB infection (based on a low-negative QFT result) and c) between patients with a borderline QFT result and subjects without TB infection (based on a low-negative QFT result). Includes only test data. MIG: monokine induced by interferon (IFN)-γ; IP-10: 10 kDa IFN-γ-induced protein; IL-1ra: interleukin-1 receptor antagonist; AUC: area under the curve.