FIGURE 5.

Biomarker values by QuantiFERON-TB Gold Plus categories: a) 10 kDa interferon (IFN)-γ-induced protein (IP-10), b) monokine induced by IFN-γ (MIG) and c) interleukin-1 receptor antagonist (IL-1ra). Biomarker values (medians and quartiles) are displayed as boxes, with whiskers representing 5–95% percentiles. Significant differences between groups were calculated using the Mann–Whitney U-test. Dashed lines represent the optimal cut-off (Youden index) derived from receiver operating characteristic curves (supplementary figure S3). All data were log₂-transformed prior to analysis. Includes all data. ****: p<0.0001; ns: nonsignificant.