Table 3.
Comparison of predicted volume reductions six to twelve months after RT found in literature, assuming a mean dose of 30 Gy. RT – radiotherapy, WBRT – whole brain radiotherapy.
| Publication | cohort | number of patients | time after RT [months] | Hippocampus | Amygdala | Putamen | Thalamus | Pallidum | Caudate |
|---|---|---|---|---|---|---|---|---|---|
| [17] | RT of grade II-IV gliomas | 31 | 12 | 4.9 % | 9.0 % | 24.3 % | 34.5 % | 41.2 % | 3.0 % |
| [16] | WBRT of METs with 30 Gy | 20 | 6–10 | 5.7 % | 4.9 % | 2.5 % | 6.9 % | −2.4 % | 9.7 % |
| 8–11 | 9.2 % | - | - | - | - | - | |||
| [30] | RT of primary brain tumours | 52 | 12 | - | 5.1% | - | - | - | - |
| [31] | identical to [30] | 6 %* | - | - | - | - | - | ||
| [32] | RT of glioblastoma patients | 14 | <6 | n.s. | - | - | - | - | - |
| This study | RT of grade II-IV gliomas | 91 | 12 | 5.2 %** | 3.1 %** | 1.7 %** | 3.4 %** | 1.8 %** | 1.2 %** |
** mean of left and right structure.
* mean dose > 40 Gy.
– not assessed.
bold significant.
n.s. no significant change.