OPLS-DA models built for LC-TOF/MS data collected for A – first ESI + experiment (R2 = 0.963, Q2 = 0.535); B – first ESI- experiment (R2 = 0.882, Q2 = 0.614); C – second ESI + experiment (R2 = 0.703, Q2 = 0.474); D – second ESI- experiment (R2 = 0.656, Q2 = 0.398). Green circles and red triangles represent healthy volunteers and RCC/ccRCC patients, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)