Table 3.
Effect of methanol extract of Grewia asiatica Linn. leaves (MEGA) on different anti-anxiety models. Elevated plus maze model (A), Light/dark box model (B), Mirror chamber model (C).
| Groups | Elevated plus maze model (A) |
Light and dark chamber model (B) |
Mirror chamber model (C) |
|||
|---|---|---|---|---|---|---|
| No. of entries in open arm | Time spent in open arm (s) | No. of entries in light box | Time spent in light box (s) | Time spent in mirrored chamber (s) | Latency time (s) | |
| Control | 4.8 ± 0.189 | 10 ± 1.34 | 4 ± 0.64 | 70 ± 2.48 | 6 ± 0.98 | 100 ± 7.41 |
| Diazepam (2 mg/kg) | 11.5 ± 1.24 | 62 ± 4.78 | 24 ± 2.56 | 150 ± 8.69 | 26 ± 1.24 | 42 ± 3.33 |
| MEGA (100 mg/kg) | 7 ± 1.36 | 28 ± 4.66 | 12 ± 2.25 | 99 ± 4.65 | 14 ± 1.33 | 79 ± 4.82 |
| MEGA (200 mg/kg) | 9 ± 1.86 | 40 ± 3.31 | 16 ± 1.36 | 118 ± 7.69 | 18 ± 2.22 | 60 ± 3.45 |
| MEGA (400 mg/kg) | 9.8 ± 1.34 | 42 ± 6.15 | 18 ± 1.22 | 119 ± 8.76 | 16 ± 2.13 | 61 ± 3.73 |
Values were expressed as Mean ± SEM, n = 6. Data was analyzed by one-way ANOVA followed by Tukey's test. a = p < 0.05 vs. control group; b = p < 0.05 vs. standard.