Table 2.
Summary of macrophage markers used by the 11 included studies. Arg-1: Arginase 1; FTY720: Fingolimod; IL-1α: Interleukin 1 alpha; IL-1β: Interleukin 1 beta; IL-4/IL-13: The combined treatment of interleukin-4 (IL-4) and IL-13; IL-6: Interleukin 6; IL-10: Interleukin 10; IL-12: Interleukin 12; iNOS: Inducible nitric oxide synthase; LMHFV: Low-magnitude high-frequency vibration; Mac1SAP: Mac-1 Sap conjugated antibody; MaR1: Maresin 1; MHCII: Major histocompatibility complex class II; MSR1: Macrophage scavenger receptor 1; OSM: Oncostatin M; PLX3397: Pexidartinib; TNF-α: Tumour necrosis factor α; 1,25(OH)2D: 1,25-Dihydroxyvitamin D.
| First Author, Year | Intervention | Macrophage markers | M1 macrophage markers (or M1 phenotype markers) | M2 macrophage markers (or M2 phenotype markers) |
|---|---|---|---|---|
| Wang, 2016 | FTY720 | CD68 | N/A | N/A |
| Sandberg, 2017 | Clodronate liposomes | F4/80+, CD68 | N/A | N/A |
| Schlundt, 2018 | IL-4/IL-13 | CD68 | CD80 | CD206, CD163 |
| Wasnik, 2018 | 1,25(OH)2D | F4/80+/CD11b+ | IL-1α, IL-1β, OSM, TNF-α, IL-6, IL-12, iNOS |
Arg-1 |
| Chow, 2019 | LMHFV | CD68 | iNOS | CD206 |
| Xu, 2019 | Trehalose | N/A | TNF-α, IL-1β, IL-6 | Arg-1, IL-10 |
| Clark, 2020 | PLX3397 | N/A | N/A | N/A |
| Hozain, 2020 | Mac1SAP toxin | F4/80+/CD11b+ | F4/80+/MHCII+/CD86+/CDllb+, F4/80+/iNOS+ | F4/80+/Arg-1+ |
| Huang, 2020 | MaR1 | N/A | iNOS | Arg-1 |
| Zhao, 2020 | Macrophage GIT1 depletion | F4/80 | iNOS | CD206 |
| Zhao, 2020 | Macrophage MSR1 knockout | F4/80 | iNOS, IL1β | CD206, CD163 |